Detalhe da pesquisa
1.
Pharmacokinetics, pharmacodynamics and safety of the novel C-X-C chemokine receptor 3 antagonist ACT-777991: Results from the first-in-human study in healthy adults.
Br J Clin Pharmacol
; 90(2): 588-599, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37752659
2.
Assessment of Pharmacokinetic Drug-Drug Interactions in Humans: In Vivo Probe Substrates for Drug Metabolism and Drug Transport Revisited.
Annu Rev Pharmacol Toxicol
; 59: 507-536, 2019 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30156973
3.
Reactive electrophilic oxylipins trigger a heat stress-like response through HSFA1 transcription factors.
J Exp Bot
; 67(21): 6139-6148, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27811081
4.
In vitro validation of an in vivo phenotyping drug cocktail for major drug transporters in humans.
Eur J Pharm Sci
; 186: 106459, 2023 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37142000
5.
Mind the Gap: Model-Based Switching from Selatogrel to Maintenance Therapy with Oral P2Y12 Receptor Antagonists.
Biomolecules
; 13(9)2023 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37759765
6.
Modeling time-delayed concentration-QT effects with ACT-1014-6470, a novel oral complement factor 5a receptor 1 (C5a1 receptor) antagonist.
Pharmacol Res Perspect
; 11(4): e01112, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37470156
7.
Transition from Syringe to Autoinjector Based on Bridging Pharmacokinetics and Pharmacodynamics of the P2Y12 Receptor Antagonist Selatogrel in Healthy Subjects.
Clin Pharmacokinet
; 61(5): 687-695, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34961905
8.
Influence of hepatic impairment on the pharmacokinetics and pharmacodynamics of the P2Y12 receptor antagonist selatogrel.
Clin Transl Sci
; 15(8): 1906-1915, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35583936
9.
First-in-human study with ACT-1014-6470, a novel oral complement factor 5a receptor 1 (C5aR1) antagonist, supported by pharmacokinetic predictions from animals to patients.
Basic Clin Pharmacol Toxicol
; 131(2): 114-128, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35596117
10.
Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin.
Sci Rep
; 10(1): 12457, 2020 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32719417
11.
A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions.
Clin Pharmacokinet
; 59(6): 781-808, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31853755
12.
A Clinical Drug-Drug Interaction Study Assessing a Novel Drug Transporter Phenotyping Cocktail With Adefovir, Sitagliptin, Metformin, Pitavastatin, and Digoxin.
Clin Pharmacol Ther
; 106(6): 1398-1407, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31247117
13.
Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?
Clin Pharmacol Ther
; 104(6): 1249-1259, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29633238
14.
Response to "Impact of Acute Alcohol Exposure on P-Glycoprotein Function at the Blood-Brain Barrier Assessed Using 11 C-Metoclopramide PET Imaging".
Clin Pharmacol Ther
; 105(4): 814, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30515759